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During the trial, hepatic transaminase elevations two consecutive measurements for alt and or ast 3 x uln occurred in four 3 individuals in the zetia coadministered with simvastatin group and in two 2 individuals in the simvastatin monotherapy group.

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Tell your doctor and pharmacist about all of your drugsprescription or OTCnatural productsvitaminsand health problemsYou must check to make sure that it is safe for you to take Zetiaezetimibewith all of your drugs and health problemsDo not startstopor change the dose of any drug without checking with your doctor.

The efficacy and safety of coadministration of ezetimibe with fibrates other than fenofibrate have not been studied.

Take this medication by mouth as directed by your doctorusually once daily with or without food.

The effect of ZETIA on cardiovascular morbidity and mortality has not been determined.

ZETIA reduces total-CLDL-CApo Bnon-HDL-Cand TGand increases HDL-C in patients with hyperlipidemiaAdministration of ZETIA with a statin is effective in improving serum total-CLDL-CApo Bnon-HDL-CTGand HDL-C beyond either treatment aloneAdministration of ZETIA with fenofibrate is effective in improving serum total-CLDL-CApo Band non-HDL-C in patients with mixed hyperlipidemia as compared to either treatment aloneThe effects of ezetimibe given either alone or in addition to a statin or fenofibrate on cardiovascular morbidity and mortality have not been established.

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